Apart from systemic alterations of serum CRP levels during lung diseases, there is clear evidence that CRP is also produced and secreted locally in the airways by epithelial cells such as nasal epithelial cells and the alveolar basal epithelial cell line A549 [105, 106, 107] and alveolar macrophages [108] Therefore, CRP may have direct and local effects on airway inflammation [109, 110] and contribute to bacterial clearance in the human respiratory tract [105]. The gene discussed is CRP; the disease is lung disorder.