TGFB1 and neoplasm: In addition to immune activation, RT also cause immunosuppressive effects in the tumour microenvironment due to the attraction of immunosuppressive cells such as M2 tumour-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and N2 neutrophils as well as because of the release of immunosuppressive cytokines (TGF-β and IL-10) and chemokines [37].