CD274 and neoplasm: High-dose RT (12–20 Gy in a single fraction) combined with anti-PD-1/PD-L1 antibodies for tumour-bearing mice induced abscopal effect that suppressed the growth of an unirradiated tumour re-challenged on the opposite flank, suggesting the induction of persistent systemic anti-tumour immune response by the combined therapy in tumour-bearing mouse model studies [53, 54].