CKB and cancer: We leveraged the VICC member expertise to aggregate cancer variant interpretations from six distinguished constituent knowledgebases: the Cancer Genome Interpreter Cancer Biomarkers Database (CGI), Clinical Interpretation of Variants in Cancer (CIViC), Jackson Laboratory Clinical Knowledgebase (JAX-CKB), MolecularMatch (MMatch), OncoKB and the Precision Medicine Knowledgebase (PMKB) (Supplementary Table 1)1,5,9–11.