Indeed, Pastille et al. 51 have studied the important role of Tregs in the development of CRC in ST2fl/fl;Foxp3-Cre mice, with Treg-specific ST2 deletion, they have found that IL-33/ST2 axis plays a central role in shaping an immunosuppressive environment during intestinal tumorigenesis. Here, IL1RL1 is linked to colorectal carcinoma.