IL33 and colorectal carcinoma: Moreover, Li and colleagues53 analyzed IL-33 gene expression in human CRC tissues and carried out gene enrichment analysis with TCGA Data Portal, and studied CRC proliferation in vivo by inoculating MC38 tumors in IL-33 transgenic mice and investigated the cell proliferation in vitro with primary CRC cells isolated from fresh human CRC tissues, human CRC cell line HT-29 and mouse CRC cell line MC38.