In ABC-DLBCL cell lines, the cleavages of caspase 3 and PARP were enhanced in the presence of HOIPIN-8 (Fig. 6c), and the cell death was suppressed by ZVAD (Supplementary Fig. 11c), suggesting that HOIPINs effectively induce apoptosis in ABC-DLBCL cells. This evidence concerns the gene CASP3 and diffuse large B-cell lymphoma.