In diffuse large B cell lymphoma (DLBCL), activated B cell-like DLBCL (ABC-DLBCL) is reportedly induced by constitutively elevated NF-κB activation, whereas the germinal center B cell-like DLBCL (GCB-DLBCL) is associated with defects in chromatin remodeling44,45. Here, NFKB1 is linked to diffuse large B-cell lymphoma.