In general, the chromosomal alterations involved genes such as KMT2A, FLT3, ETV6, RUNX1 and HNPRK. CN-LOHs were generally concentrated in chr 1, 2, 5q, 7, 11q and 13q, mostly in regions where genes with an impact on the survival of AML patients are located, such as FLT3 in 13q. This evidence concerns the gene RUNX1 and acute myeloid leukemia.