In order to study the cytokine profile in ALS, we analyzed pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), the anti-inflammatory cytokine IL-10 as well as cytokines that assist in T cell modulation and programming (IL-12 and IL-23) and that characterize specific T cell responses (IFN-gamma and IL-17A). This evidence concerns the gene TNF and amyotrophic lateral sclerosis.