In addition, there are increasing evidences suggesting a genetic predisposition in the pathogenesis of keratoconus, with lots of genomic loci and genes identified, including visual system homeobox 1 (VSX1)8–10, superoxide dismutase 1 (SOD1)10,11, transforming growth factor beta-induced (TGFβI)12 and microRNA 184 (MIR184)13,14. Here, TGFBI is linked to keratoconus.