The impaired hematopoiesis and splenomegaly that we observed when the NLRP3/IL-1β axis was active upon KRAS activation is very similar to the hepatosplenomegaly and pancytopenia reported in patients with activating mutations of NLRP3 that suffer from Cryopyrin-associated periodic syndrome (CAPS)29. The gene discussed is NLRP3; the disease is Splenomegaly.