In this respect, it is interesting that in both psoriasis and SLE the LL37-specific Th17-cells do exist and express Ror-ɣt but only in SLE, and not in psoriasis, they can express the TFH-markers Bcl-6 and high IL-21, at polyclonal and clonal levels. The gene discussed is IL21; the disease is systemic lupus erythematosus.