Not only are T-cells specific for LL37 (and cit-LL37) more frequent in SLE than in RA and SSc, but correlation studies strongly suggest that these cells are instrumental for production of high affinity anti-LL37 antibodies exclusively in SLE, and functional experiments show that they do not help autoantibody production in psoriasis. The gene discussed is CAMP; the disease is systemic lupus erythematosus.