It was also revealed that the combined chemo-MF therpay, combined chemo-PTT, and combined chemo-MF-PTT - based on Lf-Doxo-PMNSs could significantly reduce the volume and size of breast tumor, by inducing extrinsic (TNF-α) and intrinsic (Bax) pathways of the apoptosis. This evidence concerns the gene BAX and breast neoplasm.