A large collaborative European cohort of over 1000 patients with IPAH, HPAH and anorexigen associated PAH7, found that 15% of all patients carried a BMPR2 mutation, while all other causal variants, were each present in <1.5% of patients7 at least as judged by whole exome sequencing. Here, BMPR2 is linked to idiopathic pulmonary arterial hypertension.