In monitoring of cTnI, five patients (No. 1–5) with acute chest pain showed a significant elevation (≥20%, according to the literature)56,57 between two consecutive time points (0 h/1 h and 0 h/3 h), who were diagnosed with MI (in conjunction with clinical history, physical examination, and ECG) and required intervention treatment. Here, TNNI3 is linked to myocardial infarction.