In addition to VEGFA, BDNF is a member of the neurotrophin family of growth factors related to the canonical nerve growth factor; NECTIN2 encodes a single-pass type I membrane glycoprotein implicated in Alzheimer’s disease; AIF1 encodes allograft inflammatory factor found in activated macrophages in tissues with inflammation (Supplementary Fig. 1). This evidence concerns the gene AIF1 and early-onset autosomal dominant Alzheimer disease.