HNRNPC and cancer: In addition to the role of RBRP in the m6A recognition by interacting with IGF2BP1, the gene annotation assay demonstrated that RBRP interactors mainly involve in the regulation of RNA splicing and many splicing regulators interact with RBPR including ten hnRNP family proteins, seven splicing factors, and two small nuclear ribonucleoproteins, most of which have been reported to be involved in the regulation of the hallmarks of cancer17,35,36, suggesting that RBRP may also regulate pre-mRNA splicing to regulate tumorigenesis and cancer progression.