HLA-DQB1 and HLA-DRA have both been previously been associated with asthma (Demenais et al. 2018; Shrine et al. 2019), but each has also been associated to another phenotype; HLA-DQB1 to hypothyroidism (Pickrell et al. 2016) and HLA-DQB1 to RA (Jiang et al. 2015). This evidence concerns the gene HLA-DRA and rheumatoid arthritis.