SMAD7 and colorectal cancer: Interestingly, seven of the shared significant genes have been associated to colorectal cancers, including UTP23 (Al-Tassan et al. 2015), GREM1 (Whiffin et al. 2014), SCG5 (COGENT Study et al. 2008), SMAD7 (Hofer et al. 2017), CABLES2 (Schmit et al. 2018), LAMA5 (Houlston et al. 2010), and PREX1 (Lu et al. 2019).