TSC2 and sarcoma: In the human ewing sarcoma cell line, PRKCD could activate mTOR through phosphorylation and inactivation of TSC2 [103], while the TOR pathway has been identified to be a regulator of the cell apoptosis and autophagy in chicken small intestines induced by arsenic [104] and a key player linking specific extracellular milieu and intracellular metabolism during Salmonella infection in chicken [105].