EZH2 and ovarian carcinoma: Recently, Newphew and colleagues has also been able to restore the chemical effect of platinum in the chemoresistant breast and ovarian cancer cells using a polypeptide nucleic acids (PNAs)-based approach, blocking EZH2 domain of HOTAIR. In this experiment, the PNAs inhibited HOTAIR-EZH2 activity, subsequently reducing expression of NF-κB and corresponding proteins, IL-6 and MMP-9, which consequently culminated in decrease of tumour formation and improvement of survival chance [119].