In addition, Herbst noted that biomarker-driven studies such as the database-rich Lung-MAP study, the Keynote-495/KeyImPaCT NSCLC “umbrella” study of multiple pembrolizumab-based combinations, and a durvalumab (PD-L1 inhibitor)-based study of locally advanced NSCLC with biomarker correlation, could open the door for individualized combination immunotherapy for NSCLC patients. The gene discussed is CD274; the disease is non-small cell lung carcinoma.