However, several studies report that GLIs (especially GLI1 and GLI2) can be regulated by the cross talk with other signaling pathways in various types of cancers including melanoma, gastric cancer, colon cancer, multiple myeloma, medulloblastoma, pancreatic cancer, glioblastoma, and osteosarcoma [71–78]. The gene discussed is GLI1; the disease is medulloblastoma.