METTL3 and colorectal carcinoma: In line with METTL3 higher expression in CRC patients with vigorous glucose metabolism, LC-MS/MS (liquid chromatography-tandem mass spectrometry) (Fig. 1f) and m6A dot blot (Fig. 1g) experiments revealed that the m6A modification level was significantly increased in these CRC patients with higher FDG uptake as well.