METTL3 and colorectal carcinoma: To figure out whether alteration of METTL3 directly influence glycolytic metabolism, we measured extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in CRC cells after manipulating METTL3. Knockout or knockdown of METTL3 significantly reduced ECAR levels in HCT116 (Fig. 2e-f) and SW480 cells (Figure S2e), compared with control cells.