Downregulation of HK2 or SLC2A1 dramatically impaired METTL3-induced cell proliferation (Figure S6h) and colony formation (Figure S6i) in vitro and tumor growth in vivo (Figure S6j-l), which further supported HK2 and SLC2A1 (GLUT1) as critical target genes of METTL3 in CRC. This evidence concerns the gene METTL3 and colorectal carcinoma.