In turn, immunotherapy in forms of PD-1/PD-L1 inhibition appears to be useful in ccRCC management, and monoclonal antibodies targeting PD-1/PD-L1 may be combined with tyrosine kinase inhibitors (TKIs) and CTLA4 inhibitors [24, 25]. This evidence concerns the gene CD274 and nonpapillary renal cell carcinoma.