RPS6KB1 and meningioma: Since TMA-staining of the matched KLF4wt / KLF4K409Q meningioma samples revealed a trend towards higher expression of both p70S6K and phosphorylated p70S6K (Pho-p70S6K) in the mutated samples (Fig. 3a; Fig. S3), we decided to test the effect of Temsirolimus on cell growth in vitro.