CD40LG and infection: These figures were respectively of 12.3% (137/1112) and 14.1% (95%CI, 12.0–16.1%) with the more stringent cut-off ≥1:128 suggestive of possible infections, among which a range of 5.9 to 9.0% corresponded to recent or active infections (Phase 2 IgM ≥ 1:48).