In paraneoplastic SS, the over-production and dysregulation of inflammatory cytokines, like IL-1, IL-3, IL-6, IL-8, granulocyte colony stimulating factor (G-CSF), and granulocyte macrophage colony stimulating factor (GM-CSF), have been shown to be involved in the development of SS [38]. The gene discussed is CSF3; the disease is synovial sarcoma.