When only OSCC, OED, and NOM cases were compared, immunoreactivity for IL-8 was significantly higher in epithelial/cancer cells and in stroma of OSCCs in comparison with NOM specimens (p = 0.0073 and 0.032, respectively), whereas immunoreactivity for TNF-α was markedly higher in epithelium and stroma of OEDs in comparison with NOM cases (p = 0.019 and 0.0038, respectively) and in epithelium/cancer cells of OSCCs as compared to NOM specimens (p = 0.011). Here, TNF is linked to cancer.