When all types of specimens were included into statistical analysis, significant differences in immunoreactivity for IL-8 in stroma and for TNF-α in epithelium and stroma between oral leukoplakia without dysplasia and NOM cases (p = 0.022, p = 0.0017, and 0.047, respectively) as well as for TNF-α in epithelium between oral lichen planus without dysplasia and NOM specimens (p = 0.0071) were also revealed. Here, CXCL8 is linked to oral lichen planus.