Taken together with the facts that androgen/AR signaling is the driving force in both normal prostate development and regeneration and PCa development, both KLF5 and AR are transcription factors, and androgen appears to induce the expression of KLF5 in PCa cells [32,33], we propose that KLF5 and AR could be functionally associated with each other in prostatic carcinogenesis. The gene discussed is AR; the disease is posterior cortical atrophy.