The S. maxima extract treatment has reduced weight gain and the index of white adipose tissues, as well as induced AMP-activated protein kinase (AMPK) pathway and sirtuin 1 (SIRT1) to suppress the development of pathophysiological mechanisms associated with obesity in high-fat diet-induced obese rats [8]. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.