ACAN and atrial fibrillation: However, the genes included in our evaluation in native AF tissue COMP (FC = 3.45), ACAN (FC = 4.32), and SOX9 (FC = 2.71) have a stable higher FC and RUNX2 (FC = −11.47), BGLAP (FC = −9.78), and MMP13 (FC = −185.25) have a stable lower FC.