VEGFA and hepatocellular carcinoma: Blockade of the renin-angiotensin system with clinically relevant doses of angiotensin (AT)1R blocker (ARB: losartan) was found to inhibit both hepatocarcinogenesis [2] and progression of HCC [3] while at the same time inhibiting vascular endothelial growth factor (VEGF)-mediated neovascularization.