Many mutated proteins in neurodegenerative diseases are autophagy targets (e.g., mutated α-synuclein in Parkinson’s disease, mutated huntingtin in Huntington’s disease or mutants of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis) [120]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.