TNF receptor 2 (TNFR2) is a master switch of cell survival and proliferation [37] and, as reported earlier, antagonist antibodies targeting TNF receptor 2 (TNFR2, TNFRSF1b) can successfully downregulate immunosuppressive T regulatory cells and eliminate tumor cells that overexpress the TNFR2 oncogene for survival [38,39]. Here, TNFRSF1B is linked to neoplasm.