In addition, GN and BMP4 increased mRNA levels of thermogenic -genes, including cell death-inducing DNA fragmentation factor alpha-like effector A (Cidea), cytochrome c oxidase subunit VIIa polypeptide (Cox7a1), transmembrane protein 26 (Tmem26) and the BAT-specific genes Prdm16, Pgc1α and Ucp1 (Figure 5C). The gene discussed is TMEM26; the disease is ganglioneuroma.