ATM and cancer: Similarly, Igusa and colleagues reported that within SSc patients lacking ACA, ATA-scl70 or anti-RNApolIII autoantibodies (referred to as “CTP-negative” patients (CTP: Centromere, Topoisomerase, PolymeraseIII)), cancer risk was increased (SIR 1.83, 95% CI 1.10 to 2.86) [5].