On the basis of previous evidence [36], the time-course of the plasma BNP levels in patients with AMI could be divided into two patterns: a monophasic pattern with one peak at about 16 h after admission and a biphasic pattern with two peaks at about 16 h after admission, reflecting acute response to ischemia, and 5 days after admission, reflecting increased wall stress due to cardiac remodeling. The gene discussed is NPPB; the disease is ischemia.