CD274 and renal cell adenocarcinoma: In renal cell carcinoma (RCC) with clear cell histology, the FDA approved the use of ipilimumab with nivolumab for previously untreated advanced RCC, with intermediate- or poor-risk RCC, regardless of PD-L1 status based on CheckMate-214, an open-label, randomized (1:1) study [32,33] (Category 1).