On 5 August 2016, pembrolizumab was also approved for recurrent or metastatic head and neck squamous cell cancer (HNSCC) patients who progressed on standard platinum-based therapy (non-nasopharyngeal—Category 1; nasopharyngeal and PD-L1 positive—Category 2B as per NCCN guideline). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.