Interestingly, Dawicki et al. [48] found a novel phenotype of CD4+ Foxp3− IL-10− T cells, effective towards Th2 responses in food allergy, which are induced by DC differentiated in the presence of RA and exposed to TLR stimulation (with LPS), showing that the modulation of RA and IL-27 levels by TLR ligands modifies the balance of Treg cell subsets with different properties. This evidence concerns the gene CD4 and food allergy.