In particular, we demonstrated that r-protein uL3 is a key mediator of nucleolar stress induced by several chemotherapeutic drugs as 5-fluorouracil (5-FU), Oxaliplatinum (OHP), Actinomycin D (Act D) and Niclosamide in p53-mutated lung and p53-deleted colon cancer cells [9,10,11,12]. The gene discussed is TCN1; the disease is malignant colon neoplasm.