NSUN5, another RNA methyltransferase that is responsible for m5C in the C3782 position of human 28S rRNA, undergoes epigenetic loss in gliomas, which drives an overall depletion of protein synthesis, resulting in an adaptive translational program for survival under cellular stress and renders gliomas sensitive to bio-activatable substrates of the stress-related enzyme NAD(P)H quinone dehydrogenase 1 (NQO1) [81,82]. This evidence concerns the gene NSUN5 and central nervous system cancer.