To evaluate whether the EV-mediated transfer of microRNAs and lincRNA-p21 was related to endothelial cell activation, we analyzed the levels of three previously described genes whose expression is upregulated during tumor endothelial cell activation, GLUT1, PFKFB3, and GAPDH [33] (Figure 3L,M). This evidence concerns the gene PFKFB3 and neoplasm.