In a mouse model of irritant contact dermatitis induced by croton oil, topically applied recombinant human TRX significantly suppressed the inflammatory response by inhibiting the production of cytokines and chemokines, such as Tnf-α, Il-1β, Il-6, Cxcl1, and Mcp-1, in the skin tissues [32]. The gene discussed is IL1B; the disease is contact dermatitis.