MYC and hepatocellular carcinoma: For instance, Dd can successfully deliver oncogene inhibitors (e.g., a cap structure analog of eIF4E inhibitor and doxorubicin) to inhibit the proliferation of cancer cell cultures in vitro, reduce tumor growth by 40% in rat models of hepatocellular carcinoma (HCC), and significantly reduce the expression levels of oncogenes eIF4E and c-myc in rat tumor biopsies [36].