Of the lncRNAs discussed here, MALAT1 (in prostate cancer and multiple myeloma), HOTAIR (in NSCLC and multiple myeloma), and SPRY4-IT1 (in esophageal squamous-cell carcinoma) have been implicated as relevant biomarkers in liquid biopsies [136]. The gene discussed is SPRY4; the disease is AL amyloidosis.