Lymphangiogenesis also occurs in many preclinical cancer models and in some human cancers mainly through the production of vascular endothelial growth factor-C (VEGF-C) and VEGF-D, which signal through VEGFR-2 and VEGFR-3 and drive lymphatic endothelial cell (LEC) proliferation, migration, and survival [3]. Here, FLT4 is linked to cancer.