This growth factor, acting on cholinergic neurons by modulating the activity of two enzymes: cholineacetyltransferase and acetylcholinesterase in Alzheimer’s disease, the activity of these two enzymes is inhibited since the dysfunction of cholinergic neurons is an initial event in Alzheimer’s disease [22]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.