Hence, it is not surprising that reduction of IKAROS activity in the regulation of hematopoietic cell proliferation, survival and differentiation is induced by short DN isoforms and correlates to development of blast crisis in patients with chronic myeloid leukemia, myeloproliferative neoplasms, infant ALL, B-ALL and T-ALL [105,106,107,108]. Here, IKZF1 is linked to acute lymphoblastic leukemia.