Expression patterns of splice variants in normal versus cancer cells clearly indicates that: (i) the expression of TF isoforms is similar in multiple tumor types, suggesting that they could play a role in cancer cell biology, in some cases being even considered molecular markers [21] and (ii) for the most part, the effect of aberrant splicing of TFs affects global cellular processes, with considerable impact on cell proliferation, differentiation and cell death. The gene discussed is TF; the disease is cancer.