RAP2C and prediabetes syndrome: For the first time in the literature, we found that prediabetes induces cardiac miRNA expression changes targeting Jazf1, Zkscan1, and Rap2c. Small RNA-sequencing revealed a cardiac downregulation of rno-miR-200a-3p, rno-miR-293-5p, and rno-miR-208b-3p, and upregulation of rno-miR-141-3p and rno-miR-200c-3p in prediabetes.