Although it is not yet clear to what degree Nav1.2-mediated resurgent currents contribute to neuronal excitability, or to what degree neuronal excitability is enhanced by SCN2A epilepsy mutations that enhance persistent and/or resurgent currents, it is likely that these atypical sodium currents will enhance excitability where they occur by increasing spontaneous and repetitive firing. The gene discussed is SCN2A; the disease is epilepsy.