Epilepsy mutations in both SCN8A and SCN2A have now been shown to increase INaR. Since we have shown that the enhancement of resurgent current by the SCN8A/Nav1.6 epilepsy mutation N1768D can be selectively inhibited by CBD [45], we tested the ability of these compounds to selectively inhibit INaR in the Nav1.2 channel isoform. Here, SCN2A is linked to epilepsy.