A recent study has shown that the RB protein, phosphorylated by CDK4/6-cyclin D complex, specifically suppresses NF-κB p65 activity through direct binding and thereby inhibits the expression of NF-κB targets, including PD-L1 [97], which suggests another mechanism that promotes immune evasion in RB-deficient cancer cells. Here, NFKB1 is linked to cancer.