We speculate that the mutation of Glu184, where the N-terminal region of hSNF5171–258 binds to BAF155SWIRM, interrupts the formation of the hSNF5 and BAF155 complex, making it difficult to form chromatin-remodeling complexes and chromatin, and thereby resulting in tumor genesis. The gene discussed is SMARCC1; the disease is neoplasm.